Paul B Yu Selected Research

Bone Morphogenetic Proteins (Bone Morphogenetic Protein)

1/2021	Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva.
1/2021	Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva.
12/2020	The role of bone morphogenetic protein signaling in vascular calcification.
11/2020	Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells.
1/2020	ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension.
1/2017	Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification.
11/2016	Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.
11/2015	Bone morphogenetic protein 6 and oxidized low-density lipoprotein synergistically recruit osteogenic differentiation in endothelial cells.
7/2015	Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.
2/2015	Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation.

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Paul B Yu Research Topics

Disease

13	Myositis Ossificans (Fibrodysplasia Ossificans Progressiva) 06/2022 - 03/2009
12	Pulmonary Arterial Hypertension 12/2022 - 06/2015
11	Heterotopic Ossification (Ectopic Ossification) 01/2022 - 12/2008
7	Inflammation (Inflammations) 12/2022 - 05/2011
7	Pulmonary Hypertension 01/2022 - 01/2016
6	Vascular Remodeling 01/2019 - 02/2008
5	Hypoxia (Hypoxemia) 01/2019 - 01/2012
4	Wounds and Injuries (Trauma) 01/2021 - 01/2017
4	Atherosclerosis 12/2020 - 03/2012
4	Vascular Calcification 12/2020 - 03/2012
4	Anemia 02/2015 - 05/2011
3	Burns 01/2021 - 01/2017
3	Neoplasms (Cancer) 10/2014 - 01/2013
3	Familial Primary Pulmonary Hypertension 04/2013 - 12/2004
2	Vascular Diseases (Vascular Disease) 01/2020 - 01/2016
2	Liver Diseases (Liver Disease) 01/2019 - 12/2016
2	Portal Hypertension 01/2019 - 12/2016
2	Hypertension (High Blood Pressure) 01/2019 - 12/2016
2	Hyperaldosteronism (Conn Syndrome) 01/2018 - 01/2016
2	Atherosclerotic Plaque (Atheroma) 01/2016 - 03/2012
2	Chronic Disease (Chronic Diseases) 04/2014 - 10/2011
1	Bone Diseases (Bone Disease) 06/2022
1	Ovarian Neoplasms (Ovarian Cancer) 06/2022
1	Heart Failure 01/2022
1	Soft Tissue Injuries (Soft Tissue Injury) 01/2021
1	Edema (Dropsy) 01/2021
1	Infections 01/2021
1	Weight Loss (Weight Reduction) 01/2021
1	Lung Injury 01/2021
1	Chronic Renal Insufficiency 12/2020
1	COVID-19 01/2020
1	Autoimmune Diseases (Autoimmune Disease) 01/2020
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019
1	Fibrosis (Cirrhosis) 01/2018
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2016
1	Diffuse Intrinsic Pontine Glioma 10/2014
1	Congenital Abnormalities (Deformity) 06/2013

Drug/Important Bio-Agent (IBA)

17	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2021 - 12/2004
8	Phosphotransferases (Kinase)IBA 06/2022 - 12/2008
8	LigandsIBA 01/2021 - 05/2011
7	Type I Bone Morphogenetic Protein ReceptorsIBA 11/2016 - 12/2008
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 04/2013
5	LDN 193189IBA 01/2021 - 05/2011
5	IronIBA 04/2014 - 10/2009
4	Proteins (Proteins, Gene)FDA Link 12/2022 - 04/2013
4	activin AIBA 01/2021 - 09/2015
4	Bone Morphogenetic Protein ReceptorsIBA 01/2021 - 01/2013
4	HepcidinsIBA 04/2014 - 05/2011
3	Activins (Activin)IBA 12/2022 - 11/2016
3	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2020 - 11/2016
3	MonocrotalineIBA 11/2016 - 07/2015
3	Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)IBA 07/2015 - 12/2004
2	ACE-011IBA 12/2022 - 01/2021
2	saracatinibIBA 06/2022 - 01/2021
2	Matrix Gla ProteinIBA 12/2020 - 01/2015
2	Growth Differentiation Factor 2IBA 01/2019 - 01/2019
2	EndoglinIBA 01/2019 - 04/2013
2	Semaxinib (SU5416)IBA 11/2016 - 01/2016
2	Interleukin-6 (Interleukin 6)IBA 04/2014 - 05/2011
1	Growth Differentiation FactorsIBA 12/2022
1	activin receptor type II-A (activin A receptor, type II)IBA 12/2022
1	AntibodiesIBA 01/2022
1	Immunoglobulin G (IgG)IBA 01/2021
1	Transforming Growth Factor beta (TGF-beta)IBA 11/2020
1	PeriostinIBA 10/2020
1	Biocompatible Materials (Biomaterials)IBA 01/2019
1	Activin Receptors (Activin Receptor)IBA 01/2019
1	Pharmaceutical PreparationsIBA 01/2019
1	CollagenIBA 01/2018
1	Macrophage Migration-Inhibitory FactorsIBA 12/2016
1	Plasminogen Activators (Plasminogen Activator)IBA 11/2016
1	Spironolactone (Aldactone)FDA LinkGeneric 01/2016
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2016
1	Eplerenone (Inspra)FDA LinkGeneric 01/2016
1	AldosteroneIBA 01/2016
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2016
1	CaspasesIBA 01/2016
1	TOR Serine-Threonine KinasesIBA 01/2016
1	Platelet Endothelial Cell Adhesion Molecule-1IBA 01/2016
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2016
1	LipidsIBA 01/2016
1	Small Interfering RNA (siRNA)IBA 01/2016
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 07/2015
1	ElafinIBA 06/2015
1	dipinacoline glutamateIBA 10/2014
1	Hormones (Hormone)IBA 04/2014
1	Serine (L-Serine)FDA Link 06/2013
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 06/2013
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 06/2013
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 06/2013

Therapy/Procedure

5	Therapeutics 01/2021 - 10/2014
1	Tenotomy 01/2021
1	Critical Care (Surgical Intensive Care) 01/2020
1	Palliative Care (Palliative Therapy) 01/2020
1	Resuscitation 01/2020
1	Orthopedic Procedures 01/2019
1	Arthroplasty 01/2017
1	Oral Administration 02/2015
1	Sutures (Suture) 06/2013